Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium

Microvascular endothelial cells at the blood–brain barrier exhibit a protective phenotype, which is highly induced by biochemical and biomechanical stimuli. Amongst them, shear stress enhances junctional tightness and limits transport at capillary-like levels. Abnormal flow patterns can reduce funct...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Garcia-Polite, Fernando, Martorell, Jordi, Del Rey-Puech, Paula, Melgar-Lesmes, Pedro, O’Brien, Caroline C, Roquer, Jaume, Ois, Angel, Principe, Alessandro, Edelman, Elazer R, Balcells, Mercedes
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531355/
https://ncbi.nlm.nih.gov/pubmed/27702879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16672482
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