Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial

BACKGROUND: High-permeability pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS) and is frequently accompanied by impaired alveolar fluid clearance (AFC). AP301 enhances AFC by activating epithelial sodium channels (ENaCs) on alveolar epithelial cells, and we investigated it...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Crit Care
Egile Nagusiak: Krenn, Katharina, Lucas, Rudolf, Croizé, Adrien, Boehme, Stefan, Klein, Klaus Ulrich, Hermann, Robert, Markstaller, Klaus, Ullrich, Roman
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531100/
https://ncbi.nlm.nih.gov/pubmed/28750677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13054-017-1795-x
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