Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy

BACKGROUND: We investigated whether GSTT1 (“null” allele), GSTM1 (“null”allele), GSTP1 (A313G), RFC1 (G80A), MTHFR (C677T), TS (2R/3R) polymorphisms were associated with toxicity and survival in patients with early breast cancer (EBC) treated with adjuvant chemotherapy (CT). METHODS: This prospectiv...

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Bibliografski detalji
Izdano u:BMC Cancer
Glavni autori: Ludovini, Vienna, Antognelli, Cinzia, Rulli, Antonio, Foglietta, Jennifer, Pistola, Lorenza, Eliana, Rulli, Floriani, Irene, Nocentini, Giuseppe, Tofanetti, Francesca Romana, Piattoni, Simonetta, Minenza, Elisa, Talesa, Vincenzo Nicola, Sidoni, Angelo, Tonato, Maurizio, Crinò, Lucio, Gori, Stefania
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530465/
https://ncbi.nlm.nih.gov/pubmed/28747156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3483-2
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