Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital

The carcinogenic potential of phenobarbital (PB) was assessed in a mouse line carrying a mutant Mmh allele of the Mmh/Ogg1 gene encoding the enzyme oxoguanine DNA glycosylase (Ogg1) responsible for the repair of 8-hydroxy-2′-deoxyguanosine (8-OHdG). Mmh homozygous mutant (Ogg1(−/−)) and wild-type (O...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Kakehashi, Anna, Ishii, Naomi, Okuno, Takahiro, Fujioka, Masaki, Gi, Min, Fukushima, Shoji, Wanibuchi, Hideki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5530452/
https://ncbi.nlm.nih.gov/pubmed/28785378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/8541064
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