Aberrant Activation of the GIMAP Enhancer by Oncogenic Transcription Factors in T-cell Acute Lymphoblastic Leukemia

The transcription factor TAL1/SCL is one of the most prevalent oncogenes in T-cell acute lymphoblastic leukemia (T-ALL), a malignant disorder resulting from leukemic transformation of thymus T-cell precursors. TAL1 is normally expressed in hematopoietic stem cells (HSCs) but is silenced in immature...

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Bibliographic Details
Published in:Leukemia
Main Authors: Liau, Wei-Siang, Tan, Shi Hao, Ngoc, Phuong Cao Thi, Wang, Chelsia Qiuxia, Tergaonkar, Vinay, Feng, Hui, Gong, Zhiyuan, Osato, Motomi, Look, A. Thomas, Sanda, Takaomi
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529293/
https://ncbi.nlm.nih.gov/pubmed/28028313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.392
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