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Stereospecific Synthesis of Methyl 2-Amino-2-deoxy-(6S)-deuterio-α,β-D-glucopyranoside and Methyl 2,6-Diamino-2,6-dideoxy-(6R)-deuterio-α,β-D-glucopyranoside: Side Chain Conformations of the 2-Amino-2-deoxy and 2,6-Diamino-2,6-Dideoxyglucopyranosides

The stereospecifically labeled 6-monodeuterio methyl 2,6-diamino-2,6-dideoxy-α- and β-D-glucopyranosides were synthesized with a view to determining their side chain conformations. NMR studies in D(2)O at pH 5 and pH 11 reveal both anomers to adopt very predominantly the gt conformation consistent w...

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Bibliographic Details
Published in:Carbohydr Res
Main Authors: Kato, Takayuki, Vasella, Andrea, Crich, David
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529286/
https://ncbi.nlm.nih.gov/pubmed/28554123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2017.05.015
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