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Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal

Leukemia inhibitory factor (LIF) is required, but not sufficient, for pluripotent mouse embryonic stem (ES) cell expansion in vitro in the absence of serum or a feeder cell layer, suggesting that additional signals are provided by serum or feeders that are necessary to support self-renewal. Here we...

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Detalhes bibliográficos
Main Authors: Yamane, Toshiyuki, Dylla, Scott J., Muijtjens, Manja, Weissman, Irving L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC552922/
https://ncbi.nlm.nih.gov/pubmed/15728354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500167102
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