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Conditioning and Robustness of RNA Boltzmann Sampling under Thermodynamic Parameter Perturbations
Understanding how RNA secondary structure prediction methods depend on the underlying nearest-neighbor thermodynamic model remains a fundamental challenge in the field. Minimum free energy (MFE) predictions are known to be “ill conditioned” in that small changes to the thermodynamic model can result...
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| 發表在: | Biophys J |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Biophysical Society
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5529178/ https://ncbi.nlm.nih.gov/pubmed/28629618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.05.026 |
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