Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4)

The maintenance of photoreceptor cell polarity is compromised by the rhodopsin mutations causing the human disease autosomal dominant retinitis pigmentosa. The severe form mutations occur in the C-terminal sorting signal of rhodopsin, VXPX-COOH. Here, we report that this sorting motif binds specific...

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Bibliographische Detailangaben
Hauptverfasser: Deretic, Dusanka, Williams, Andrew H., Ransom, Nancy, Morel, Valerie, Hargrave, Paul A., Arendt, Anatol
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC552909/
https://ncbi.nlm.nih.gov/pubmed/15728366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500095102
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