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Secretome and degradome profiling shows that Kallikrein‐related peptidases 4, 5, 6, and 7 induce TGFβ‐1 signaling in ovarian cancer cells

Kallikrein‐related peptidases, in particular KLK4, 5, 6 and 7 (4–7), often have elevated expression levels in ovarian cancer. In OV‐MZ‐6 ovarian cancer cells, combined expression of KLK4–7 reduces cell adhesion and increases cell invasion and resistance to paclitaxel. The present work investigates h...

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Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Shahinian, Hasmik, Loessner, Daniela, Biniossek, Martin L., Kizhakkedathu, Jayachandran N., Clements, Judith A., Magdolen, Viktor, Schilling, Oliver
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528505/
https://ncbi.nlm.nih.gov/pubmed/24120346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.09.003
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