Secretome and degradome profiling shows that Kallikrein‐related peptidases 4, 5, 6, and 7 induce TGFβ‐1 signaling in ovarian cancer cells

Kallikrein‐related peptidases, in particular KLK4, 5, 6 and 7 (4–7), often have elevated expression levels in ovarian cancer. In OV‐MZ‐6 ovarian cancer cells, combined expression of KLK4–7 reduces cell adhesion and increases cell invasion and resistance to paclitaxel. The present work investigates h...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Shahinian, Hasmik, Loessner, Daniela, Biniossek, Martin L., Kizhakkedathu, Jayachandran N., Clements, Judith A., Magdolen, Viktor, Schilling, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528505/
https://ncbi.nlm.nih.gov/pubmed/24120346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.09.003
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