Lipoplex mediated silencing of membrane regulators (CD46, CD55 and CD59) enhances complement‐dependent anti‐tumor activity of trastuzumab and pertuzumab

The therapeutic potential of anticancer antibodies is limited by the resistance of tumor cells to complement‐mediated attack, primarily through the over‐expression of membrane complement regulatory proteins (mCRPs: CD46, CD55 and CD59). Trastuzumab, an anti‐ HER2 monoclonal antibody, approved for th...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Mamidi, Srinivas, Cinci, Marc, Hasmann, Max, Fehring, Volker, Kirschfink, Michael
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2013
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Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528480/
https://ncbi.nlm.nih.gov/pubmed/23474221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.02.011
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