Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes

Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 (H3K27me3). H3K27me3 is characteristic of the chromatin at genes involved in developmental regulation in undifferentiated c...

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Holm, Karolina, Grabau, Dorthe, Lövgren, Kristina, Aradottir, Steina, Gruvberger-Saal, Sofia, Howlin, Jillian, Saal, Lao H., Ethier, Stephen P., Bendahl, Pär-Ola, Stål, Olle, Malmström, Per, Fernö, Mårten, Rydén, Lisa, Hegardt, Cecilia, Borg, Åke, Ringnér, Markus
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2012
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528390/
https://ncbi.nlm.nih.gov/pubmed/22766277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.06.002
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