SIRT1 and NAD+ precursors: Therapeutic targets in multiple sclerosis a review

Neurodegeneration is an important determinant of disability in multiple sclerosis (MS) but while currently approved treatments reduce inflammation, they have not been shown to reduce neurodegeneration. SIRT1, a NAD dependent protein deacetylase, has been implicated in the pathogenesis of neurodegene...

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Pubblicato in:J Neuroimmunol
Autori principali: Nimmagadda, Vamshi K.C., Makar, Tapas K., Chandrasekaran, Krish, Sagi, Avinash Rao, Ray, Jayanta, Russell, James W., Bever, Christopher T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528149/
https://ncbi.nlm.nih.gov/pubmed/27474445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2016.07.007
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