Overexpression of SIRT1 protein in neurons protects against Experimental Autoimmune Encephalomyelitis through activation of multiple SIRT1 targets

Treatment of experimental autoimmune encephalomyelitis (EAE) with Resveratrol, an activator of Sirtuin 1 (SIRT1), reduces disease severity. This suggested that activators of SIRT1, a highly conserved nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase, might have immune-modulating...

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Autors principals: Nimmagadda, Vamshi K., Bever, Christopher T., Vattikunta, Narasimha R., Talat, Saifi, Ahmad, Vakas, Nagalla, Naveen K., Trisler, David, Judge, Susan I. V., Royal, Walter, Chandrasekaran, Krish, Russell, James W., Makar, Tapas K.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963275/
https://ncbi.nlm.nih.gov/pubmed/23547115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202584
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