Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma

Deregulated monoubiquitination of histone H2B (H2Bub1), mainly catalyzed by E3 ubiquitin-protein ligase RNF20/RNF40 complex, may play an important role in cancer. Here we investigate potential roles of H2Bub1 and the underlying mechanisms through which it contributes to cancer development and progre...

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Vydáno v:Int J Cancer
Hlavní autoři: Zhang, Keqiang, Wang, Jinhui, Tong, Tommy R., Wu, Xiwei, Nelson, Rebecca, Yuan, Yate-Ching, Reno, Theresa, Liu, Zheng, Yun, Xinwei, Kim, Jae Y., Salgia, Ravi, Raz, Dan J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527746/
https://ncbi.nlm.nih.gov/pubmed/28481029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.30769
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