Overexpression of Flap Endonuclease 1 Correlates with Enhanced Proliferation and Poor Prognosis of Non–Small-Cell Lung Cancer

Flap endonuclease 1 (FEN1) plays a crucial role in both DNA replication and damage repair. In this study, FEN1 expression and its clinical-pathologic significance in non–small-cell lung cancer (NSCLC) was investigated. Quantitative RT-PCR and immunohistochemistry analysis identified that both FEN1 m...

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Publicado en:Am J Pathol
Autores principales: Zhang, Keqiang, Keymeulen, Sawa, Nelson, Rebecca, Tong, Tommy R., Yuan, Yate-Ching, Yun, Xinwei, Liu, Zheng, Lopez, Joshua, Raz, Dan J., Kim, Jae Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745529/
https://ncbi.nlm.nih.gov/pubmed/29037854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.09.011
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