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In Vivo 11β-Hydroxysteroid Dehydrogenase Inhibition in Posaconazole-Induced Hypertension and Hypokalemia

We describe a case of apparent mineralocorticoid excess (AME) secondary to posaconazole therapy and suggest the biochemical mechanism. Clinical and laboratory investigation confirmed 11β-hydroxysteroid dehydrogenase inhibition and withholding therapy led to a resolution of all clinical and laborator...

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發表在:Antimicrob Agents Chemother
Main Authors: Thompson, George R., Chang, Diana, Wittenberg, Rebecca R., McHardy, Ian, Semrad, Alison
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527645/
https://ncbi.nlm.nih.gov/pubmed/28533238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00760-17
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