Antibiotic Resistance as a Stress Response: Recovery of High-Level Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus “Auxiliary” (fem) Mutants by Induction of the Stringent Stress Response

Studies with methicillin-resistant Staphylococcus aureus (MRSA) strain COL have shown that the optimal resistance phenotype requires not only mecA but also a large number of “auxiliary genes” identified by Tn551 mutagenesis. The majority of auxiliary mutants showed greatly increased levels of oxacil...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Kim, Choon Keun, Milheiriço, Catarina, de Lencastre, Hermínia, Tomasz, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527599/
https://ncbi.nlm.nih.gov/pubmed/28630179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00313-17
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