Multiregion ultra‐deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer

Intratumor heterogeneity (ITH) contributes to cancer progression and chemoresistance. We sought to comprehensively describe ITH of somatic mutations, copy number, and transcriptomic alterations involving clinically and biologically relevant gene pathways in colorectal cancer (CRC). We performed mult...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Suzuki, Yuka, Ng, Sarah Boonhsi, Chua, Clarinda, Leow, Wei Qiang, Chng, Jermain, Liu, Shi Yang, Ramnarayanan, Kalpana, Gan, Anna, Ho, Dan Liang, Ten, Rachel, Su, Yan, Lezhava, Alexandar, Lai, Jiunn Herng, Koh, Dennis, Lim, Kiat Hon, Tan, Patrick, Rozen, Steven G., Tan, Iain Beehuat
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527459/
https://ncbi.nlm.nih.gov/pubmed/28145097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12012
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