A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure

Analysis of hematopoietic stem cells (HSCs) in factor VIII knockout (FVIIIKO) mice revealed a novel regulatory role for the coagulation cascade in hematopoiesis. Thus, HSCs in FVIIIKO mice had reduced proportions of CD34(low) cells within Lin(−)Sca(+)Kit(+) progenitors, and exhibited reduced long-te...

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Veröffentlicht in:Blood
Hauptverfasser: Aronovich, Anna, Nur, Yaniv, Shezen, Elias, Rosen, Chava, Zlotnikov Klionsky, Yael, Milman, Irit, Yarimi, Liran, Hagin, David, Rechavi, Gidi, Martinowitz, Uriel, Nagasawa, Takashi, Frenette, Paul S., Tchorsh-Yutsis, Dalit, Reisner, Yair
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527398/
https://ncbi.nlm.nih.gov/pubmed/23982175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-08-447458
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