Site-specific cleavage of duplex DNA by a semisynthetic nuclease via triple-helix formation.
A Lys-84----Cys mutant staphylococcal nuclease was selectively linked to the 5' and/or 3' terminus of a thiol-containing polypyrimidine oligonucleotide via a disulfide bond. The oligonucleotide-staphylococcal nuclease adduct is capable of binding to a homopurine-homopyrimidine region of Watson-Crick...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55273/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2124705/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.24.9858 |
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