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Permeability Barrier and Microstructure of Skin Lipid Membrane Models of Impaired Glucosylceramide Processing

Ceramide (Cer) release from glucosylceramides (GlcCer) is critical for the formation of the skin permeability barrier. Changes in β-glucocerebrosidase (GlcCer’ase) activity lead to diminished Cer, GlcCer accumulation and structural defects in SC lipid lamellae; however, the molecular basis for this...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Sochorová, Michaela, Staňková, Klára, Pullmannová, Petra, Kováčik, Andrej, Zbytovská, Jarmila, Vávrová, Kateřina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527096/
https://ncbi.nlm.nih.gov/pubmed/28744000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06990-7
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