Thrombopoiesis is spatially regulated by the bone marrow vasculature

In mammals, megakaryocytes (MKs) in the bone marrow (BM) produce blood platelets, required for hemostasis and thrombosis. MKs originate from hematopoietic stem cells and are thought to migrate from an endosteal niche towards the vascular sinusoids during their maturation. Through imaging of MKs in t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Stegner, David, vanEeuwijk, Judith M. M., Angay, Oğuzhan, Gorelashvili, Maximilian G., Semeniak, Daniela, Pinnecker, Jürgen, Schmithausen, Patrick, Meyer, Imke, Friedrich, Mike, Dütting, Sebastian, Brede, Christian, Beilhack, Andreas, Schulze, Harald, Nieswandt, Bernhard, Heinze, Katrin G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527048/
https://ncbi.nlm.nih.gov/pubmed/28743899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00201-7
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