New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

The synthesis and molecular characterization of new isatin-based hydrazonoindolin-2-ones 4a-o and 7a-e are reported. The in vitro anti-proliferative potential of the synthesized compounds 4a-o and 7a-e was examined against HT-29 (colon), ZR-75 (breast) and A549 (lung) human cancer cell lines. Compou...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Attia, Mohamed I., Eldehna, Wagdy M., Afifi, Samar A., Keeton, Adam B., Piazza, Gary A., Abdel-Aziz, Hatem A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526551/
https://ncbi.nlm.nih.gov/pubmed/28742842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181241
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