Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase: New clues into catalytic mechanism

Dihydroneopterin triphosphate pyrophosphatase (DHNTPase), a member of the Mg(2+) dependent Nudix hydrolase superfamily, is the recently-discovered enzyme that functions in the second step of the pterin branch of the folate biosynthetic pathway in E. coli. DHNTPase is of interest because inhibition o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hill, Shannon E., Nguyen, Elaine, Ukachukwu, Chiamaka U., Freeman, Dana M., Quirk, Stephen, Lieberman, Raquel L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526541/
https://ncbi.nlm.nih.gov/pubmed/28742822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180241
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