The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities

A Nudix enzyme from Bacillus cereus (NCBI RefSeq accession no. NP_831800) catalyzes the hydrolysis of CDP-choline to produce CMP and phosphocholine. Here, we show that in addition, the enzyme has a 3′→5′ RNA exonuclease activity. The structure of the free enzyme, determined to a 1.8-Å resolution, sh...

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Bibliographic Details
Main Authors: Duong-Ly, Krisna C., Gabelli, Sandra B., Xu, WenLian, Dunn, Christopher A., Schoeffield, Andrew J., Bessman, Maurice J., Amzel, L. Mario
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Enzymes and Proteins
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133267/
https://ncbi.nlm.nih.gov/pubmed/21531795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00089-11
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