The lysosomal protein cathepsin L is a progranulin protease

Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia. Receptor-mediated lysosomal targeting has been shown to regulate brain PGRN levels, and complete deficiency of PGRN is a direct caus...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Lee, Chris W., Stankowski, Jeannette N., Chew, Jeannie, Cook, Casey N., Lam, Ying-Wai, Almeida, Sandra, Carlomagno, Yari, Lau, Kwok-Fai, Prudencio, Mercedes, Gao, Fen-Biao, Bogyo, Matthew, Dickson, Dennis W., Petrucelli, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526245/
https://ncbi.nlm.nih.gov/pubmed/28743268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0196-6
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