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N6′, N6‴, and O4′-Modifications to Neomycin Affect Ribosomal Selectivity Without Compromising Antibacterial Activity
The synthesis of a series of neomycin derivatives carrying the 2-hydroxyethyl substituent on N6′ and/or N6‴ both alone and in combination with a 4′-O-ethyl group is described. By means of cell-free translation assays with wild-type bacterial ribosomes and their hybrids with eukaryotic decoding A sit...
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| Publicado no: | ACS Infect Dis |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5526222/ https://ncbi.nlm.nih.gov/pubmed/28343384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00214 |
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