Efficient Enzymatic Cyclization of an Inhibitory Cystine Knot-Containing Peptide

Disulfide-rich peptides isolated from cone snails are of great interest as drug leads due to their high specificity and potency toward therapeutically relevant ion channels and receptors. They commonly contain the inhibitor cystine knot (ICK) motif comprising three disulfide bonds forming a knotted...

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Bibliografiske detaljer
Udgivet i:Biotechnol Bioeng
Main Authors: Kwon, Soohyun, Bosmans, Frank, Kaas, Quentin, Cheneval, Olivier, Conibear, Anne C., Rosengren, K. Johan, Wang, Conan K., Schroeder, Christina I., Craik, David J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526200/
https://ncbi.nlm.nih.gov/pubmed/27093300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.25993
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