Transgenic SCs expressing GDNF-IRES-DsRed impair nerve regeneration within cellular nerve allografts

Providing temporally-regulated glial cell line-derived neurotrophic factor (GDNF) to injured nerve can promote robust axon regeneration. However, it is poorly understood why providing highly elevated levels of GDNF to nerve can lead to axon entrapment in the zone containing elevated GDNF. This limit...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biotechnol Bioeng
Main Authors: Ee, Xueping, Yan, Ying, Hunter, Daniel A., Schellhardt, Lauren, Sakiyama-Elbert, Shelly E., Mackinnon, Susan E., Wood, Matthew D.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526100/
https://ncbi.nlm.nih.gov/pubmed/28481001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26335
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