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Transgenic SCs expressing GDNF-IRES-DsRed impair nerve regeneration within cellular nerve allografts

Providing temporally-regulated glial cell line-derived neurotrophic factor (GDNF) to injured nerve can promote robust axon regeneration. However, it is poorly understood why providing highly elevated levels of GDNF to nerve can lead to axon entrapment in the zone containing elevated GDNF. This limit...

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Dades bibliogràfiques
Publicat a:Biotechnol Bioeng
Autors principals: Ee, Xueping, Yan, Ying, Hunter, Daniel A., Schellhardt, Lauren, Sakiyama-Elbert, Shelly E., Mackinnon, Susan E., Wood, Matthew D.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526100/
https://ncbi.nlm.nih.gov/pubmed/28481001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26335
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