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Transgenic SCs expressing GDNF-IRES-DsRed impair nerve regeneration within cellular nerve allografts

Providing temporally-regulated glial cell line-derived neurotrophic factor (GDNF) to injured nerve can promote robust axon regeneration. However, it is poorly understood why providing highly elevated levels of GDNF to nerve can lead to axon entrapment in the zone containing elevated GDNF. This limit...

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Publicado en:Biotechnol Bioeng
Autores principales: Ee, Xueping, Yan, Ying, Hunter, Daniel A., Schellhardt, Lauren, Sakiyama-Elbert, Shelly E., Mackinnon, Susan E., Wood, Matthew D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5526100/
https://ncbi.nlm.nih.gov/pubmed/28481001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26335
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