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mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss
It is unknown whether and how VLDLR impacts skeletal homeostasis. Here we report that maternal and offspring VLDLR play opposite roles in osteoclastogenesis and bone resorption. VLDLR deletion in the offspring augments osteoclast differentiation by enhancing RANKL signaling, leading to osteoporosis....
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| Pubblicato in: | Cell Rep |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5526096/ https://ncbi.nlm.nih.gov/pubmed/28591574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.037 |
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