Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

BACKGROUND: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholest...

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Publicado en:BioData Min
Autores principales: Holzinger, Emily R., Verma, Shefali S., Moore, Carrie B., Hall, Molly, De, Rishika, Gilbert-Diamond, Diane, Lanktree, Matthew B., Pankratz, Nathan, Amuzu, Antoinette, Burt, Amber, Dale, Caroline, Dudek, Scott, Furlong, Clement E., Gaunt, Tom R., Kim, Daniel Seung, Riess, Helene, Sivapalaratnam, Suthesh, Tragante, Vinicius, van Iperen, Erik P.A., Brautbar, Ariel, Carrell, David S., Crosslin, David R., Jarvik, Gail P., Kuivaniemi, Helena, Kullo, Iftikhar J., Larson, Eric B., Rasmussen-Torvik, Laura J., Tromp, Gerard, Baumert, Jens, Cruickshanks, Karen J., Farrall, Martin, Hingorani, Aroon D., Hovingh, G. K., Kleber, Marcus E., Klein, Barbara E., Klein, Ronald, Koenig, Wolfgang, Lange, Leslie A., Mӓrz, Winfried, North, Kari E., Charlotte Onland-Moret, N., Reiner, Alex P., Talmud, Philippa J., van der Schouw, Yvonne T., Wilson, James G., Kivimaki, Mika, Kumari, Meena, Moore, Jason H., Drenos, Fotios, Asselbergs, Folkert W., Keating, Brendan J., Ritchie, Marylyn D.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5525436/
https://ncbi.nlm.nih.gov/pubmed/28770004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13040-017-0145-5
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