Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

BACKGROUND: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholest...

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Vydáno v:BioData Min
Hlavní autoři: Holzinger, Emily R., Verma, Shefali S., Moore, Carrie B., Hall, Molly, De, Rishika, Gilbert-Diamond, Diane, Lanktree, Matthew B., Pankratz, Nathan, Amuzu, Antoinette, Burt, Amber, Dale, Caroline, Dudek, Scott, Furlong, Clement E., Gaunt, Tom R., Kim, Daniel Seung, Riess, Helene, Sivapalaratnam, Suthesh, Tragante, Vinicius, van Iperen, Erik P.A., Brautbar, Ariel, Carrell, David S., Crosslin, David R., Jarvik, Gail P., Kuivaniemi, Helena, Kullo, Iftikhar J., Larson, Eric B., Rasmussen-Torvik, Laura J., Tromp, Gerard, Baumert, Jens, Cruickshanks, Karen J., Farrall, Martin, Hingorani, Aroon D., Hovingh, G. K., Kleber, Marcus E., Klein, Barbara E., Klein, Ronald, Koenig, Wolfgang, Lange, Leslie A., Mӓrz, Winfried, North, Kari E., Charlotte Onland-Moret, N., Reiner, Alex P., Talmud, Philippa J., van der Schouw, Yvonne T., Wilson, James G., Kivimaki, Mika, Kumari, Meena, Moore, Jason H., Drenos, Fotios, Asselbergs, Folkert W., Keating, Brendan J., Ritchie, Marylyn D.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5525436/
https://ncbi.nlm.nih.gov/pubmed/28770004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13040-017-0145-5
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