In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs

More than 2 million bone-grafting procedures are performed each year using autografts or allografts. However, both options carry disadvantages, and there remains a clear medical need for the development of new therapies for massive bone loss and fracture nonunions. We hypothesized that localized ult...

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Détails bibliographiques
Publié dans:Sci Transl Med
Auteurs principaux: Bez, Maxim, Sheyn, Dmitriy, Tawackoli, Wafa, Avalos, Pablo, Shapiro, Galina, Giaconi, Joseph C., Da, Xiaoyu, Ben David, Shiran, Gavrity, Jayne, Awad, Hani A., Bae, Hyun W., Ley, Eric J., Kremen, Thomas J., Gazit, Zulma, Ferrara, Katherine W., Pelled, Gadi, Gazit, Dan
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524999/
https://ncbi.nlm.nih.gov/pubmed/28515335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal3128
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