In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs

More than 2 million bone-grafting procedures are performed each year using autografts or allografts. However, both options carry disadvantages, and there remains a clear medical need for the development of new therapies for massive bone loss and fracture nonunions. We hypothesized that localized ult...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Principais autores: Bez, Maxim, Sheyn, Dmitriy, Tawackoli, Wafa, Avalos, Pablo, Shapiro, Galina, Giaconi, Joseph C., Da, Xiaoyu, Ben David, Shiran, Gavrity, Jayne, Awad, Hani A., Bae, Hyun W., Ley, Eric J., Kremen, Thomas J., Gazit, Zulma, Ferrara, Katherine W., Pelled, Gadi, Gazit, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524999/
https://ncbi.nlm.nih.gov/pubmed/28515335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal3128
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