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Overexpression of DNMT3b target genes during Enteric Nervous System development contribute to the onset of Hirschsprung disease

Hirschsprung disease (HSCR) is attributed to a failure of neural crest cells (NCCs) to migrate, proliferate, differentiate and/or survive in the bowel wall during embryonic Enteric Nervous System (ENS) development. ENS formation is the result from a specific gene expression pattern regulated by epig...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Villalba-Benito, Leticia, Torroglosa, Ana, Fernández, Raquel María, Ruíz-Ferrer, Macarena, Moya-Jiménez, María José, Antiñolo, Guillermo, Borrego, Salud
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524929/
https://ncbi.nlm.nih.gov/pubmed/28740121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06539-8
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