In Vivo Sub-chronic Treatment with Dichlorvos in Young Rats Promotes Synaptic Plasticity and Learning by a Mechanism that Involves Acylpeptide Hydrolase Instead of Acetylcholinesterase Inhibition. Correlation with Endogenous β-Amyloid Levels

Acylpeptide hydrolase (APEH) is a serine hydrolase that displays two catalytic activities, acting both as an exopeptidase toward short N-acylated peptides and as an endopeptidase toward oxidized peptides or proteins. It has been demonstrated that this enzyme can degrade monomers, dimers, and trimers...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: García-Rojo, Gonzalo, Gámiz, Fernando, Ampuero, Estíbaliz, Rojas-Espina, Daniel, Sandoval, Rodrigo, Rozas, Carlos, Morales, Bernardo, Wyneken, Ursula, Pancetti, Floria
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524899/
https://ncbi.nlm.nih.gov/pubmed/28790916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00483
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