TGF-β1 Downregulates the Expression of CX(3)CR1 by Inducing miR-27a-5p in Primary Human NK Cells

Activity of human natural killer (NK) cells against cancer cells is deeply suppressed by TGF-β1, an immunomodulatory cytokine that is released and activated in the tumor microenvironment. Moreover, our previous data showed that TGF-β1 modifies the chemokine receptor repertoire of NK cells. In partic...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Regis, Stefano, Caliendo, Fabio, Dondero, Alessandra, Casu, Beatrice, Romano, Filomena, Loiacono, Fabrizio, Moretta, Alessandro, Bottino, Cristina, Castriconi, Roberta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524732/
https://ncbi.nlm.nih.gov/pubmed/28791023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00868
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