Novel Molecule Exhibiting Selective Affinity for GABA(A) Receptor Subtypes

Aminoquinoline derivatives were evaluated against a panel of receptors/channels/transporters in radioligand binding experiments. One of these derivatives (DCUK-OEt) displayed micromolar affinity for brain γ-aminobutyric acid type A (GABA(A)) receptors. DCUK-OEt was shown to be a positive allosteric...

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發表在:Sci Rep
Main Authors: Borghese, Cecilia M., Herman, Melissa, Snell, Lawrence D., Lawrence, Keri J., Lee, Hyun-Young, Backos, Donald S., Vanderlinden, Lauren A., Harris, R. Adron, Roberto, Marisa, Hoffman, Paula L., Tabakoff, Boris
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524711/
https://ncbi.nlm.nih.gov/pubmed/28740086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05966-x
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