EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation

In multiple myeloma (MM) osteolytic lesions rarely heal because of persistent suppressed osteoblast differentiation resulting in a high fracture risk. Herein, chromatin immunoprecipitation analyses reveal that MM cells induce repressive epigenetic histone changes at the Runx2 locus that prevent oste...

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Udgivet i:Mol Cancer Res
Main Authors: Adamik, Juraj, Jin, Shunqian, Sun, Quanhong, Zhang, Peng, Weiss, Kurt R., Anderson, Judith L., Silbermann, Rebecca, Roodman, G. David, Galson, Deborah L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524543/
https://ncbi.nlm.nih.gov/pubmed/28119431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0242-T
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