EZH2 supports osteoclast differentiation and bone resorption via epigenetic and cytoplasmic targets

Key osteoclast (OCL) regulatory gene promoters in bone marrow derived monocytes harbor bivalent histone modifications that combine activating Histone 3 lysine 4 tri-methyl (H3K4me3) and repressive H3K27me3 marks, which upon RANKL stimulation resolve into repressive or activating architecture. Enhanc...

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Bibliographic Details
Published in:J Bone Miner Res
Main Authors: Adamik, Juraj, Pulugulla, Sree H., Zhang, Peng, Sun, Quanhong, Lontos, Konstantinos, Macar, David A., Auron, Philip E., Galson, Deborah L.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7402427/
https://ncbi.nlm.nih.gov/pubmed/31487061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3863
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