Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults

Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are rare histiocytic disorders induced by somatic mutation of MAPK pathway genes. BRAF(V600E) mutation is the most common mutation in both conditions and also occurs in the hematopoietic neoplasm hairy cell leukemia (HCL). It is n...

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Publicado en:Blood
Main Authors: Milne, Paul, Bigley, Venetia, Bacon, Chris M., Néel, Antoine, McGovern, Naomi, Bomken, Simon, Haniffa, Muzlifah, Diamond, Eli L., Durham, Benjamin H., Visser, Johannes, Hunt, David, Gunawardena, Harsha, Macheta, Mac, McClain, Kenneth L., Allen, Carl, Abdel-Wahab, Omar, Collin, Matthew
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2017
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524529/
https://ncbi.nlm.nih.gov/pubmed/28512190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-12-757823
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