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Histiocytic disorders: insights into novel biology and implications for therapy of Langerhans cell histiocytosis and Erdheim-Chester disease

Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are caused by mutations of the MAPK pathway, most often BRAFV(600E), in myeloid dendritic cells that lead to some overlapping and other unique presentations of the two diseases. LCH occurs in both children and adults, but ECD is p...

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Vydáno v:Hematology Am Soc Hematol Educ Program
Hlavní autor: McClain, Kenneth
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7727507/
https://ncbi.nlm.nih.gov/pubmed/33275721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/hematology.2020000159
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