Critical role of water molecules in proton translocation by the membrane-bound transhydrogenase

The nicotinamide nucleotide transhydrogenase (TH) is an integral membrane enzyme that uses the proton motive force to drive hydride transfer from NADH to NADP(+) in bacteria and eukaryotes. Here we solved a 2.2 Å crystal structure of the TH transmembrane domain (Thermus thermophilus) at pH 6.5. This...

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Main Authors: Padayatti, Pius S., Leung, Josephine H., Mahinthichaichan, Paween, Tajkhorshid, Emad, Ishchenko, Andrii, Cherezov, Vadim, Soltis, S. Michael, Jackson, J. Baz, Stout, C. David, Gennis, Robert B., Zhang, Qinghai
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524145/
https://ncbi.nlm.nih.gov/pubmed/28648609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.05.022
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