Division of Labor in Transhydrogenase by alternating proton translocation and hydride transfer

NADPH/NADP(+) homeostasis is critical for countering oxidative stress in cells. Nicotinamide nucleotide transhydrogenase (TH), a membrane enzyme present in both bacteria and mitochondria, couples the proton motive force to the generation of NADPH. We present the 2.8 Å crystal structure of the transm...

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Udgivet i:Science
Main Authors: Leung, Josephine H., Schurig-Briccio, Lici A., Yamaguchi, Mutsuo, Moeller, Arne, Speir, Jeffrey A., Gennis, Robert B., Stout, Charles D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479213/
https://ncbi.nlm.nih.gov/pubmed/25574024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1260451
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