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Division of Labor in Transhydrogenase by alternating proton translocation and hydride transfer
NADPH/NADP(+) homeostasis is critical for countering oxidative stress in cells. Nicotinamide nucleotide transhydrogenase (TH), a membrane enzyme present in both bacteria and mitochondria, couples the proton motive force to the generation of NADPH. We present the 2.8 Å crystal structure of the transm...
Sparad:
| I publikationen: | Science |
|---|---|
| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4479213/ https://ncbi.nlm.nih.gov/pubmed/25574024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1260451 |
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