Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress

BACKGROUND: The amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects gene and protein expression in a variety of pathwa...

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Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Qin, Pu, Arabacilar, Pelin, Bernard, Roberta E., Bao, Weike, Olzinski, Alan R., Guo, Yuanjun, Lal, Hind, Eisennagel, Stephen H., Platchek, Michael C., Xie, Wensheng, del Rosario, Julius, Nayal, Mohamad, Lu, Quinn, Roethke, Theresa, Schnackenberg, Christine G., Wright, Fe, Quaile, Michael P., Halsey, Wendy S., Hughes, Ashley M., Sathe, Ganesh M., Livi, George P., Kirkpatrick, Robert B., Qu, Xiaoyan A., Rajpal, Deepak K., Faelth Savitski, Maria, Bantscheff, Marcus, Joberty, Gerard, Bergamini, Giovanna, Force, Thomas L., Gatto, Gregory J., Hu, Erding, Willette, Robert N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524058/
https://ncbi.nlm.nih.gov/pubmed/28487390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.004453
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