Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening

BACKGROUND: The cardiac microvascular system ischemia/reperfusion injury following percutaneous coronary intervention is a clinical thorny problem. This study explores the mechanisms by which ischemia/reperfusion injury induces cardiac microcirculation collapse. METHODS AND RESULTS: In wild‐type mic...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Zhou, Hao, Hu, Shunying, Jin, Qinhua, Shi, Chen, Zhang, Ying, Zhu, Pingjun, Ma, Qiang, Tian, Feng, Chen, Yundai
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524036/
https://ncbi.nlm.nih.gov/pubmed/28288978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.005328
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