In vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses Against Extracellular Antigens()

There is a compelling need for more effective vaccine adjuvants to augment induction of antigen specific adaptive immune responses. Recent reports suggested the bacterial second messenger bis-(3′–5′)-cyclic-dimeric-guanosine monophosphate (c-di-GMP) acts as an innate immune system modulator. We rece...

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Vydáno v:J Immunol
Hlavní autoři: Alyaqoub, Fadel S., Aldhamen, Yasser A., Koestler, Benjamin J., Bruger, Eric L., Seregin, Sergey S., Pereira-Hicks, Cristiane, Godbehere, Sarah, Waters, Christopher M., Amalfitano, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523134/
https://ncbi.nlm.nih.gov/pubmed/26792800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501272
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