The prohibitin-repressive interaction with E2F1 is rapidly inhibited by androgen signalling in prostate cancer cells

Prohibitin (PHB) is a tumour suppressor molecule with pleiotropic activities across several cellular compartments including mitochondria, cell membrane and the nucleus. PHB and the steroid-activated androgen receptor (AR) have an interplay where AR downregulates PHB, and PHB represses AR. Additional...

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Bibliographische Detailangaben
Veröffentlicht in:Oncogenesis
Hauptverfasser: Koushyar, S, Economides, G, Zaat, S, Jiang, W, Bevan, C L, Dart, D A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523065/
https://ncbi.nlm.nih.gov/pubmed/28504694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.32
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